Ovulation Induction Treatment | Ovulation Induction Medication
Ovulation Induction

Ovulation Induction Treatment and Medication

Studies suggest that 25- 30% of women who experience fertility issues experience them due to ovulation problems. Irregular menstruation, prolonged menstrual cycles, chronic pelvic pain during menstrual periods are some of the signs that indicate irregular ovulation.

Ovulation is the process where the eggs are released from the ovary during a menstrual cycle. One egg is normally released per ovulation cycle. In cases where ovulation occurs irregularly, Ovulation induction Treatment (OIT); a fertility treatment process employed to accomplish ovulation or release one or more eggs from the ovary, is considered. Ovulation Induction can be a process during the Intrauterine Insemination (IUI) or In Vitro Fertilization (IVF) procedures.

A successful IVF requires an adequate number of good-quality eggs that can get fertilized and later transferred. Ovulation Induction medication that regulates ovulation and helps increase the number of eggs produced in a cycle and in turn increase the possibility of a successful pregnancy.

How does Ovulation Induction Treatment work?

Ovulation induction is the first step of IVF or IUI procedures. This step is crucial as it aids the production of good viable eggs.

A careful examination of the ovary status and analysis of the ovulation cycle is done. Some of the common diagnostic tests done include:

  • Hormonal assay to check the levels of hormones including progesterone and prolactin.
  • Hysterosalpingography to examine the uterus.
  • Ovarian reserve testing to check the number of good quality eggs generated.
  • A check of pituitary and thyroid hormones involved in the reproductive process.
  • Ultrasound of the pelvic region to evaluate the reproductive organs.

If a woman has been diagnosed with improper ovulation and ovulation induction is recommended, then the treatment for infrequent ovulation with hormonal medications is generally prescribed.

  • The treatment starts with medications to enhance the production of mature eggs.
  • The medications of ovulation induction depend on the hormones regulating hypothalamus, pituitary, and ovarian function.
  • If the hypothalamic function is adequate, estrogen inhibitors are administered orally. These estrogen inhibitors like Clomiphene citrate inhibits estrogen receptors and stimulates the release of gonadotropins inducing follicular development.
  • If there is hypothalamic-pituitary dysfunction, injectable gonadotropins ( a combination of FSH and LH ) are administered.
  • Once the follicles develop adequately, an injection of hCG is given to trigger ovulation.
  • Generally, the eggs are released within 36 hours of hCG administration. Once the eggs are released, the fertilization window is open for about 36 hours, to fertilize with the sperm through timed intercourse or artificial insemination.

The whole procedure is performed with blood tests and necessary ultrasound to check the hormonal levels and status of the ovaries.

The Ovulation Induction cycle:

The medication and treatment in ovulation Induction are designed according to the menstrual cycle of a woman. The ovulation induction cycle starts on the first day of a menstrual cycle. The day-wise protocols of an ovulation induction cycle are:

  • DAY 1: Necessary blood tests are performed on the day 1 of menstruation.
  • DAY 2 to DAY 4: medications and hormonal interventions are initiated.
  • DAY 10 to DAY 11: A blood test to check the hormone levels is done. If necessary, even an ultrasound can be performed.
  • DAY 14: An ultrasound test on day 14 of the ovulation cycle will help determine the status of ovulation.

For women who have an irregular menstrual cycle, ovulation may occur after day 14. However, it is important to note that regular visits to the clinic are necessary until the ovulation process is complete.

Ovulation Induction Medications

A sequence of fertility medicines during ovulation induction include:

ESTROGEN BLOCKERS (CLOMIPHENE CITRATE): Anti-estrogen medications block the estrogen receptors which stimulate the production of follicle-stimulating hormones (FSH).

Clomiphene citrate is a common fertility agent used to induce superovulation or release of multiple eggs in a single menstrual cycle.

It is observed that when these medications were used for women with ovulation issues, fertility was achieved even without artificial insemination. And for women with unexplained infertility, clomiphene citrate is used when ovulation induction and intrauterine insemination are combined.

HUMAN MENOPAUSAL GONADOTROPIN: Human menopausal gonadotropin (hMG) is a medication that is a composition of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Both the hormones are necessary for egg development and hMG is used in injectable form. However, there is no fixed dosage of this medication and can vary depending on the patient’s condition. This hormonal input is stronger than oral medication and can be used with both IUI and IVF techniques.

FOLLICLE STIMULATING HORMONE: Follicle Stimulating Hormone (FSH) medications are used to stimulate the development of multiple eggs during an ovulation induction cycle. FSH can also be used in combination with hMG to encourage ovulation.

HUMAN CHORIONIC GONADOTROPIN (hCG): This is a natural hormone and also multifunctional.

  • It assists the eggs to mature.
  • It is also known to stimulate ovulation
  • It also stimulates the secretion of progesterone that in turn will help thicken the uterus for implantation of the embryo (fertilized ovum).

Generally, Ovulation occurs approximately after 36 hours of hCG administration.

LUPRON (LEUPROLIDE) TREATMENT: Lupron can suppress the release of pituitary hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that are responsible for the release of estrogen and other reproductive hormones. This creates a “temporary menopause” stage. Lupron is used to improve the quality and quantity of eggs in IVF cycles. It also prepares the uterine lining for embryo transfer.

IVF Ovulation

Ovulation Induction can induce and manage the ovulation cycle. Induction is known to increase the success rates of IVF and can improve the chances of a successful conceiving through IVF.

Ovulation induction, if considered, is the first step of the IVF process which is important to obtain an adequate number of mature eggs required for fertilization. Since the entire ovulation is monitored meticulously, it allows egg retrieval for IVF at the right time i.e when they are mature and yet to be released from the ovaries.

The use of hormonal medications during ovulation induction stimulates the production of a number of mature eggs, and thus increasing the possibilities of a successful pregnancy. The extra eggs and embryos obtained can be frozen and stored for later use.

Ovulation Therapy

Every therapy or treatment has its own set of benefits as well as risk factors.

Benefits of Ovulation therapy include:

  • Ovulation induction is a non-invasive treatment and can be the first option to treat infertility in women relating to irregular menstrual cycles.
  • Ovulation induction can improve the success rates of treatments including intrauterine insemination (IUI), IVF, etc.

Risk factors and side-effects include:

One major risk of this treatment is Ovarian Hyperstimulation Syndrome (OHSS) which can have mild to severe side effects such as nausea, bloating, pain, and swelling of the pelvic region. However, it is observed that these side-effects subside in a few days.

Ovulation Induction Treatment at IVF Junction

Ovulation Induction can help gain fertility for people suffering from issues of irregular ovulation. Hormonal medications used during ovulations are imbibed in a way similar to a regular menstrual cycle. IVF Junction connects you with our network of fertility centres at Delhi NCR and Gurgaon. Our Specialists can help you through the whole process of ovulation Induction that can enhance the possibilities of a successful conceiving.

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